KOREA UNIVERSITY Department of Chemical and Biological Engineering

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Research Area

BT (Biotechnology)

1. Bioprocess Engineering Laboratory
Bioprocess Engineering Laboratory

In 1997, Bioprocess Engineering Laboratory (BPEL) was established by Prof. Seung Wook Kim of Chemical and Biological Engineering Department, Korea University. With a long history, our laboratory has always revolved around the frontier researches of bioprocess engineering. Nowadays, the major research topics of BPEL cover all aspects of bioprocess engineering, which include metabolic engineering, bioenergy production, enzymatic fuel cell and development of nano-sensor. As a laboratory member of Brain Korea 21, we are conducting various research projects which focus on strain development, biomass pretreatment, biorefinery conversion, high performance enzymatic fuel cell and biosensors. The advance facilities provide all-round supporting to students and research professors on their scientific studies. BPEL encourages every researcher to study bold in innovation with conscientious scholarship.

Grand achievements of biotechnologies have been acquired by BPEL in last decades: advance immobilization of enzymes/cells, strain mutant with genetic engineering, and statistical optimization of bioconversion process for instance. More than 200 research SCI papers have been published in international journals. Over 60 patents have been achieved by BPEL and some of them have already successfully applied in industry. The open-platform of research life style is offered by BPEL with multiple cultures, and new ideas are always sparkled in this confluent academic atmosphere. With the mutual culture of our laboratory, Prof. Kim and the seniors lead students to create new history of BPEL with bright perspective.



Homepage : http://prosys.korea.ac.kr/lab/bio/
  • For more information, contact : Prof. Seung Wook Kim
  • Tel : 82-2-3290-3300
  • Email : kimsw@korea.ac.kr
2. Systems Bioengineering Laboratory
Systems Bioengineering Laboratory

Our laboratory has interests in the metabolic engineering for production of fuels and chemicals from biomass. In order to construct the desirable microbial strains that can produce industrially valuable products in cost effective way, our laboratory is equipped with experimental tools for engineering living organisms. First, we are developing gene cloning, deletion, and genome editing tools and are applying those techniques for achieving maximal effectiveness in the microbial system. Second, we are trying to develop synthetic biology tools, providing novel biological components or modules to build artificial genetic circuits inside the strain. Also, we are equipped with metabolomics and fluxomics, systems biology approaches to understand the chemical reactions in the living organisms. In our lab, we are trying to design and engineer living microorganism for industrial purpose with the synthetic and systems biology approaches.



Homepage : sysbio.korea.ac.kr
  • For more information, contact : Prof. Min-Kyu Oh
  • Tel : 82-2-3290-3308
  • Email : mkoh@korea.ac.kr
3. Nanobiocatalysis Laboratory
Nanobiocatalysis Laboratory

Nanobiocatalysis Laboratory is demonstrating unprecedented successes in stabilizing enzyme activities via original approaches of enzyme coatings (ECs), nanoscale enzyme reactors (NERs) and single enzyme nanoparticles (SENs). These approaches are developed based on the introduction of nanomaterials, and corresponding chemical conjugation strategies, for the immobilization of enzymes. Our studies have revealed that once enzymes are immobilized and stabilized in the form of nanobiocatalysis, they exhibit long lifetime under harsh storage conditions and can be easily reused for multiple times. Based on its stability and reusability, we are demonstrating successful applications of nanobiocatalysis in various fields including biofuel cells, biosensors, trypsin digestions, ELISA, antifouling and CO2 conversion.



Homepage : http://nbc.korea.ac.kr
  • For more information, contact : Prof. Jungbae Kim
  • Tel : 82-2-3290-4850
  • Email : jbkim3@korea.ac.kr
4. Biomolecular Engineering Laboratory
Biomolecular Engineering Laboratory

The Biomolecular Engineering Laboratory, founded by professor Jeewon Lee, has focused on biomolecular process engineering such as LFA-based diagnostics, In vivo imaging, Photothermal therapy of cancer, and Synthetic pro-peptide design. We reported a variety of nanoparticle proteins such as cancer targeting peptides, specific disease detection particles, fusion peptides for enhancement of protein secretion in eukaryotes, and nano-vaccines for multiple precaution through one injection.

In addition, we constructed new platforms of the nanoparticle which have characteristics, non-toxicity in vivo, intensive structure, and reasonable price. Currently, we also studies on immunotherapy, nano-enzyme for high value material production, and gene silencing cancer therapy. Finally, these protein nano particles are developed for application in pharmaceutical and biochemical industries.



Homepage : http://bmel.korea.ac.kr
  • For more information, contact : Prof. Jeewon Lee
  • Tel : 82-2-3290-3304
  • Email : leejw@korea.ac.kr
5. Nanobiotechnology Laboratory
Nanobiotechnology Laboratory

The Nanobiotechnology Laboratory, founded by Professor Sang Jun Sim, is conducting research on various nano-biotechnology techniques focused on early diagnosis and environmental issues.

The research team is currently promoting various projects, which can be applied to various disease models, including cancers and Alzheimer’s disease. Such projects include utilizing inorganic substances such as gold nanoparticles and polyacetylene to actualize molecular imaging technology; developing a next generation nano-biosensor system, which can be commercialized; developing LSPR and Raman darkfield microscope with a supersensitive detection technology along with surface reforming technology; applying various receptor technologies; and enhancing imagery using an amplifier.

Also, our research interest includes the reduction of CO2 in the atmosphere using microalgae for preventing global warming. We are developing poly(dimethylsiloxane) (PDMS)-based integrated microfluidic platforms to perform high-throughput screening of the excellent mutants and multiple steps in sample preparation on a single device for efficient and quantitative analysis of lipid from various microalgal strains. We are also constructing CO2 reduction biological process using microalgae with highly efficient photobioreactors. These approaches will provide novel and efficient solutions for the improvement of photosynthetic productivity of microalgae, which is essential for commercialization of biological conversion of CO2 into microalgal biomass and products.



Homepage : http://nanobiotec.korea.ac.kr
  • For more information, contact : Prof. Sang Jun Sim
  • Tel : 82-2-3290-4853
  • Email : simsj@korea.ac.kr